EXOARC®: A Point-of-care Plasma Isolation Platform
ExoArc enables gentle and high-purity plasma separation using novel microfluidic hydrodynamic forces generated by Dean vortices, preserving biomarkers critical for time-sensitive diagnostics.
Principle
Inlet:
Whole blood enters the sample inlet while a clean sheath buffer enters the second inlet. The two liquids flow side-by-side in laminar flow.
Cross Section:
Inside the curved microchannel, Dean vortices drive particles toward the inner wall. Smaller components like cfDNA/RNA and platelets travel closer to the wall and migrate faster than larger blood cells. As they move along the top and bottom channel walls, size-dependent lift forces push larger cells further away from the wall. These subtle positional differences allow precise separation of plasma, platelets, and blood cells into different outlets.
Outlet:
Blood cells and platelets were clearly separated from plasma, resulting in a cell-free, platelet-free plasma
